New Customers Get 10% Off – Use Code: LUX10

TB-500

5.0 Reviews

TB4Thymosin Beta-4Thymosin β4Tβ4

A 43-amino acid synthetic fragment of thymosin beta-4 studied for its modulation of actin polymerization and cell migration in laboratory research models. For laboratory research use only.

All products currently listed on this site are for research purposes only.

Original price was: $39.99.Current price is: $35.99.

2 Day FAST Shipping

99%+ Purity Tests

Ships from USA

USA Lab Tested

We accept :

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

How TB-500 Works

The Science, Simplified

Actin Sequestration & Cell Motility

TB-500 is a synthetic fragment of the naturally occurring 43-amino acid protein, Thymosin Beta-4. Its primary mechanism involves binding to G-actin (globular actin), preventing its polymerization into F-actin.
Key insight: By regulating actin dynamics, TB-500 is studied for its role in actin regulation and cell migration in research models, where upregulation of cell migration pathways is observed under laboratory conditions.

Potent Angiogenic Signaling

TB-500 is one of the most powerful peptides for stimulating angiogenesis—the formation of new blood vessels from pre-existing ones.

Key insight: It upregulates Vascular Endothelial Growth Factor (VEGF), increasing the density of the capillary network in injured areas. This improved vascularity ensures that oxygen and nutrients are delivered directly to tissues that typically have poor blood supply, such as tendons and ligaments.

Differentiation of Stem Cells

Research indicates that TB-500 influences the differentiation of progenitor cells, specifically those involved in creating new muscle fibers and dermal tissue.

Key insight: Beyond just moving cells, TB-500 helps “recruit” stem cells to injured or inflamed areas and encourages them to transform into the appropriate tissue types needed for structural repair.

Research Handling Notes

What research literature describes

Handled as a research chemical under standard laboratory protocols.

Storage & Handling

10%

Store lyophilized at -20°C

note

4%

Reconstitute with bacteriostatic water for laboratory use

note

3%

Protect from light

note

Safety Advantage

Versatile Administration

  • Low Molecular Weight: TB-500 has a low molecular weight that is studied in distribution research models under laboratory conditions.
  • Non-Binding to Bone: Unlike certain growth factors, TB-500 does not bind to the bone matrix, reducing the risk of unwanted calcification in soft tissues.
  • Low Toxicity: Preclinical toxicology studies report no significant findings.

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is TB-500?

CAS Number

77591-33-4

Molecular Weight

4,963 Da

Amino Acids

43

Active Region

Ac-SDKP (N-terminal)

Key Sequence

17LKKTET22 (actin binding)

Expert Opin Biol Ther (2012)

🧊 Storage Requirements

Stability Information

Lyophilized (powder)

-20°C

stable long-term

Reconstituted

2-8°C

use within 14-30 days

Avoid

Repeated freeze-thaw exposure

📊 Physical Properties

Research Status

Classification

Actin-Modulating Research Peptide

Origin

Derived from Thymosin Beta-4 (Tβ4)

Publications

1,000+ peer-reviewed studies

Primary Research Area

Angiogenesis and Tissue Remodeling

Frequently Asked Questions

Common questions about TB-500

Thymosin Beta-4 is the full-length, naturally occurring protein (43 amino acids). TB-500 is a synthetic "fragment" (typically 7 amino acids) that represents the most active region studied for actin regulation and cell migration. In the research community, the names are often used interchangeably, but TB-500 is the version specifically synthesized for laboratory use.
Both are studied in cell-migration research but through different pathways. BPC-157 is often researched for its localized pathway activity in laboratory models. TB-500 is researched for its actin-modulating role in cell migration. Researchers may study them together as a "dual-pathway" approach in laboratory models.
In research models, TB-500 is characterized by its systemic distribution. Its low molecular weight and high mobility allow it to distribute broadly to target tissues in laboratory studies.
It must be reconstituted with Bacteriostatic Water. Once the liquid is added, the vial should be gently swirled. Never shake the vial, as the kinetic energy can damage the delicate peptide bonds.
No. TB-500 is currently classified as an investigational research compound. It is not approved for human or veterinary use and is sold strictly for laboratory experiments and scientific evaluation.

Sources & References

Peer-reviewed research

Expert Opinion on Biological Therapy

Thymosin β4: a multi-functional peptide — basic molecular properties (PubMed 22074294)

2012

Goldstein AL, Hannappel E, Sosne G, Kleinman HK

View Source

Annals of the New York Academy of Sciences

Thymosin beta4: a randomized, placebo-controlled pharmacokinetic research study (PubMed 20536472)

2010

Ruff D, Crockford D, Girardi G, Zhang Y

View Source

Journal of the Neurological Sciences

A Dose Response Study of Thymosin β4 for the Treatment of Acute Stroke

2014

Morris DC, Cui Y, Cheung WL, Lu M, Zhang L, Zhang ZG, Chopp M

View Source

Journal of Investigative Dermatology

Thymosin beta4 tissue-migration research study (PubMed 10469335)

1999

Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

View Source

International Journal of Molecular Sciences (PMC)

Progress on the Function and Application of Thymosin β4

2021

Xing Y, et al.

View Source

Nature

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

2004

Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D

View Source

Clinical Ophthalmology

Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II study

2015

Sosne G, Ousler GW

View Source

Neuroscience

Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke

2010

Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG

View Source

Journal of Neurosurgery

Treatment of traumatic brain injury with thymosin beta4 in rats

2010

Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

My Account
Follow Us
Linkedin X-twitter Icon-instagram-1 Facebook-square