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SEMAX

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CAS: 129954-34-3SelancThr-Lys-Pro-Arg-Pro-Gly-Pro

A 7-amino acid synthetic heptapeptide analog of ACTH (4–10) studied for its modulation of BDNF expression and TrkB signaling pathways in laboratory research models. For laboratory research use only.

All products currently listed on this site are for research purposes only.

Price range: $72.00 through $180.00

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How SEMAX Works

The Science, Simplified

Neurotrophic Factor Upregulation

Semax is a synthetic heptapeptide analog of a fragment of ACTH (adrenocorticotropic hormone). A mechanism characterized in research models is the elevation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF).
Key observation: Elevated levels of these neurotrophic factors are associated with neuronal survival and growth pathways. In laboratory models, this has been reported alongside changes in synaptic plasticity markers, a process studied in neuroscience research

Selective Neurotransmitter Modulation

In research models, Semax is observed to modulate the dopaminergic and serotonergic systems without associated receptor depletion.

Key observation: Research models indicate modulation of dopaminergic signaling pathways. Activity within the serotonergic system has also been documented as a research observation.

Transcriptome & Ischemic Protection

Semax has a profound effect on gene expression, specifically suppressing genes related to inflammation while activating genes involved in neurotransmission.

Key observation: This “transcriptome compensation” makes it a subject of interest in ischemia and neural injury research models. In ischemic research models, exposure to Semax has been associated with changes in tissue markers and neural function endpoints under study.

Research Handling Notes

What research literature describes

Handled as a research chemical under standard laboratory protocols. The compound is stable when stored and handled according to the notes below.

🧿 Storage & Handling

10%

Store lyophilized at -20°C

note

8%

Reconstitute with bacteriostatic water for laboratory use

note

5%

Protect from light

note

Safety Advantage

Non-Hormonal Design

  • Non-Hormonal Structure: Although derived from ACTH, Semax is structurally modified to lack hormonal activity. In research models it does not exhibit adrenal stimulation or cortisol-modulating activity characteristic of native ACTH.
  • Non-Accumulating: Research literature describes no dependence-forming properties in laboratory models.
  • Rapid Elimination: With a plasma half-life of 1-2 hours in research models, it is metabolized into constituent amino acids, limiting long-term accumulation.

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is Semax?

Type

Synthetic heptapeptide

CAS Number

80714-61-0

Molecular Formula

C37H51N9O10S

Molecular Weight

813.9 g/mol

Amino Acids

7 residues

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

PubChem Database

🧊 Storage Requirements

Stability Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Lyophilized (powder)

-20°C

protect from light

Reconstituted

2-8°C

use within 4 weeks

Nasal spray

2-8°C

30 days after opening

📋 Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Developer

Russian Academy of Sciences

Approval

Russia (1990s)

Research Areas

Ischemia & neural injury models

Formulations

0.1% and 1% nasal spray

US Status

Not FDA-approved

Related Peptide

Selank (tuftsin analog)

Wikipedia

Frequently Asked Questions

Common questions about SEMAX

No. In research models it does not act through catecholamine release like caffeine or amphetamines. Instead, it is characterized as modulating internal signaling pathways and cerebral blood flow markers rather than producing acute adrenergic stimulation.
NA-Semax (N-Acetyl Semax) is a modified version with an acetyl group added to the start of the peptide chain. In research, this modification is studied for its ability to increase the peptide's stability and its ability to cross the blood-brain barrier even more effectively than the original.
Semax is unique because it works on several levels: it reduces inflammation, protects cells from oxygen deprivation (hypoxia), and increases the production of growth factors. This multi-pathway approach is critical for protecting brain tissue during an ischemic event.
In laboratory research models, Semax is characterized by rapid transport across the blood-brain barrier. Changes in signaling markers are often observed within 30-60 minutes, while gene-expression-related effects under study may develop over several days of repeated exposure in research settings.
No. It is a prescription medication in some Eastern European countries but is classified as an investigational research compound in the United States. It is sold strictly for laboratory research and is not intended for human consumption.

Sources & References

Peer-reviewed research

Brain Research

Semax, an analog of ACTH(4-10), regulates BDNF and trkB expression in the rat hippocampus

2006

Dolotov OV, Karpenko EA, Inozemtseva LS, et al.

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BMC Genomics

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia

2014

Medvedeva EV, Dmitrieva VG, Povarova OV, et al.

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Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

2018

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Journal of Molecular Neuroscience

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action

2010

Shadrina M, Kolomin T, Agapova T, et al.

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International Journal of Molecular Sciences

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

2020

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  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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