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SELANK

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CAS: 129954-34-3SelancThr-Lys-Pro-Arg-Pro-Gly-Pro

A 7-amino acid synthetic heptapeptide derived from tuftsin, studied in research models for its effects on GABAergic neurotransmission and BDNF expression. For laboratory research use only.

All products currently listed on this site are for research purposes only.

Price range: $72.00 through $180.00

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How SELANK Works

The Science, Simplified

Receptor and Neuropeptide Mechanisms

Selank is a synthetic heptapeptide derived from tuftsin, a natural immunomodulatory peptide. In research models, it is studied for allosteric regulation of GABA-A receptors and its resulting influence on GABAergic signaling.
Key insight: In contrast to benzodiazepine receptor agonists, research literature describes Selank's GABAergic modulation as occurring through a distinct allosteric mechanism, without direct action at the benzodiazepine binding site—a distinction studied at the receptor-pharmacology level.

BDNF Expression Signaling

Selank is observed in research models to increase the expression of Brain-Derived Neurotrophic Factor (BDNF), a protein involved in neuronal signaling pathways.

Key insight: This mechanism is studied in relation to synaptic plasticity signaling pathways. In the research literature, Selank's sequence and receptor activity are referenced in studies of GABAergic and neurotrophic signaling models.

Enkephalin Protection

Selank is studied for its inhibition of the enzymes that break down enkephalins, endogenous opioid-receptor-binding peptides.

Key insight: This enzyme-inhibition activity is examined in research models alongside enkephalin signaling and neurotransmitter turnover, forming part of ongoing peptide-degradation research.

Research Handling Notes

What research literature describes

In research models, Selank is reported as chemically stable, breaking down into constituent amino acid residues during metabolic processing studies.

🧪 Laboratory Handling Notes

✓

Store lyophilized at -20°C

standard

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Reconstitute with bacteriostatic water for laboratory use

standard

✓

Protect from light

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Research Observations

Pharmacological Profile

  • Receptor Selectivity: Research literature reports GABA-A receptor modulation without measurable sedative or muscle-relaxant effects in the study models examined, distinguishing it from benzodiazepine compounds.
  • Tolerance Profile: Research literature reports no evidence of tolerance development following cessation of a study protocol, in contrast to benzodiazepine compounds.
  • Motor-Task Performance: Research literature reports no measurable impact on motor-task performance metrics recorded during study protocols.

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is Selank?

Type

Synthetic heptapeptide

CAS Number

129954-34-3

Molecular Formula

C33H57N11O9

Molecular Weight

751.9 g/mol

Amino Acids

7 residues

Sequence

Thr-Lys-Pro-Arg-Pro-Gly-Pro

PubChem Database

🧊 Storage Requirements

Stability Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Lyophilized (powder)

-20°C

protect from light

Reconstituted

2-8°C

use within 4 weeks

Aqueous solution (0.15%)

2-8°C

30 days after opening

📋 Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Developer

Russian Academy of Sciences

Collaborator

V.V. Zakusov Institute

Approval

Russia (2009), Ukraine

Indication

Generalized Anxiety Disorder

US Status

Not FDA-approved

Formulation

0.15% w/v formulation (Rx status in Russia)

Frequently Asked Questions

Common questions about SELANK

All three are studied in relation to the GABA system, but Selank does not directly bind to the benzodiazepine site. Research literature describes it as "adjusting" receptor response through a distinct allosteric mechanism, which is the basis for its continued study as a structurally and pharmacologically distinct research compound relative to Phenibut or benzodiazepine compounds.
In animal research models, Selank has been documented with a high bioavailability (~92.8%) via this delivery route. As a small peptide, its ability to cross the blood-brain barrier in these models is a pharmacokinetic property of interest in CNS-signaling research literature. This information is provided for research reference only and is not usage guidance.
Selank's effects on dopaminergic and serotonergic signaling, along with BDNF expression, are examined in research models relevant to attention and learning signaling pathways. This describes research activity only and is not a claim about outcomes in any individual.
Tuftsin is an endogenous immunomodulatory peptide. Selank was synthesized by adding three amino acids to the tuftsin sequence to increase structural stability. In addition to GABAergic and BDNF signaling research, this tuftsin-derived sequence is also studied in immunomodulation research.
No. While it has been prescribed in Russia since 2009 for Generalized Anxiety Disorder (GAD), it is currently classified in the US as an investigational research compound. It is not intended for human use and is sold strictly for laboratory scientific research.

Sources & References

Peer-reviewed research

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

2008

Zozulia AA, Neznamov GG, Siuniakov TS, et al.

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Behavioural Neurology

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017

Kasian A, Kolomin T, Andreeva L, et al.

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Frontiers in Pharmacology

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

2016

Volkova A, Shadrina M, Kolomin T, et al.

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Bulletin of Experimental Biology and Medicine

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

2019

Kozlovskii II, Andreeva LA, Myasoedov NF

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Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

2014

Medvedev VE, Tereshchenko ON, Israelian AIu, et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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