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PT-141

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Ac-Nle-cyclo[BremelanotideVyleesi

A 7-amino acid cyclic peptide analog of alpha-MSH that binds melanocortin receptors MC3R and MC4R, studied in receptor-signaling research. Premium Research Peptide.

All products currently listed on this site are for research purposes only.

$45.00

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How PT-141 Works

The Science, Simplified

Central Melanocortin Receptor Agonism

Information: PT-141 is a synthetic peptide analog of $\alpha$-Melanocyte-Stimulating Hormone ($\alpha$-MSH). It functions as a potent agonist at central melanocortin receptors, specifically MC3R and MC4R, located in the hypothalamus. Key insight: Unlike compounds studied for localized vascular signaling, PT-141 targets central nervous system receptor pathways directly, offering a distinct model for central melanocortin receptor research in both male and female research models.

Nitric Oxide Pathways

By stimulating the hypothalamic MC4R pathways, PT-141 triggers the downstream release of nitric oxide.

Key insight: In research models, this signaling cascade is associated with smooth muscle tone changes and localized vasodilation, an observation studied alongside PDE5 inhibitor signaling pathways in receptor research.

Central Neural Signaling Pathway

Because it acts directly on central nervous system signaling centers rather than localized circulation, it is studied as a distinct model from peripheral vascular-pathway compounds.

Key insight: Research literature describes central melanocortin receptor activation as mechanistically distinct from peripheral pathways, positioning PT-141 as a model compound for central neuromodulation receptor studies.

Research Handling Notes

What research literature describes

PT-141 is documented across peptide research literature analyzing its receptor-binding characteristics and handling stability, giving it one of the more thoroughly documented profiles among melanocortin research peptides.

🧿 Laboratory Handling Notes

-20°C

Store lyophilized

stable

Bact. H2O

Reconstitute for lab use

stable

UV-Safe

Protect from light

stable

Signaling Profile Notes

Comparative Receptor Data

  • Blood Pressure Signaling Profile: In contrast to PDE5 inhibitor signaling pathways, PT-141's central receptor mechanism is not associated with rapid systemic vasodilation, a distinguishing characteristic studied in receptor-signaling research models.
  • Half-Life Profile: Reported biological half-life of approximately 2.7 hours in research models, with measurable receptor-binding activity observed within 45 to 60 minutes in laboratory studies.
  • Structural Stability: The peptide features a highly stable lactam bridge cyclization that protects it from immediate enzymatic breakdown, allowing for highly predictable research windows.

Compound Information

Technical specifications

🔬 Molecular Profile

What Is PT-141?

Type

Cyclic heptapeptide

CAS Number

189691-06-3

Molecular Formula

C50H68N14O10

Molecular Weight

1025.2 g/mol

Amino Acids

7 residues

Sequence

Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

PubChem Database

🧊 Storage Requirements

Stability Information

Originally developed by Palatin Technologies as a research candidate compound

Lyophilized (powder)

2-8°C

protect from light

Reconstituted

2-8°C

use within 30 days

Reference standard vial

Room temperature

Development Status

Regulatory Information

Originally developed by Palatin Technologies as a research candidate compound

Developer

Palatin Technologies

Marketing

AMAG Pharmaceuticals

FDA Approval

June 21, 2019

Trade Name

Vyleesi

Indication

Not approved (research only)

FDA Approval Letter

Frequently Asked Questions

Common questions about PT-141

While PT-141 is structurally derived from Melanotan II, it has been engineered to reduce binding affinity at the MC1R receptor, a pigmentation-pathway receptor. This differentiates its receptor-binding profile in research models from MC1R-selective research compounds.
The biological half-life is roughly 2.7 hours. Receptor-binding activity observed in research models typically peaks between 1 to 4 hours after introduction to the assay system, with measurable activity tapering off over a 6 to 8-hour window.
Early studies explored intranasal delivery pathways alongside other routes; regulatory review of the intranasal route noted inconsistent blood-pressure-related data. Both delivery-route models remain documented in independent laboratory research literature.
The compound is the subject of an FDA-approved pharmaceutical marketed under the name Vyleesi. The raw lyophilized compound offered on this site is a separate research chemical, legally available globally and strictly designated for laboratory research use only.

Sources & References

Peer-reviewed research

Obstetrics & Gynecology

Central Melanocortin Receptor Agonism: Phase 3 Trial Data on Bremelanotide

2019 • DOI: 10.1097/AOG.0

Kingsberg SA, Clayton AH

View Source

International Journal of Impotence Research

PT-141: A Melanocortin Receptor Agonist — Mechanism and Research Findings

2004

Diamond LE, Earle DC, Rosen RC, et al.

View Source

Journal of Sexual Medicine

Bremelanotide and Central Nervous System Signaling Response: Clinical Study Findings

2006

Diamond LE, Earle DC, Heiman JR, et al.

View Source

Journal of Women's Health

Reported Event Profile of Bremelanotide Across the Clinical Development Program

2022

View Source

Medicina (Kaunas)

Bremelanotide Central Receptor Signaling: Clinical Study Data

2022

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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