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KPV

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Alpha-MSH (11-13)CAS: 67727-97-3Lysine-Proline-Valineα-MSH C-Terminal Fragment

A 3-amino acid tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-melanocyte-stimulating hormone that inhibits NF-κB activation via PepT1-mediated cellular uptake in preclinical inflammatory research models. Premium Research Peptide.

All products currently listed on this site are for research purposes only.

Original price was: $53.99.Current price is: $49.50.

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How KPV Works

The Science, Simplified

Inhibition of the NF-κB Pathway

KPV represents the C-terminal active sequence of $\alpha$-Melanocyte-Stimulating Hormone ($\alpha$-MSH). At a cellular level, it directly blocks NF-κB (Nuclear Factor kappa B), the master transcription factor that drives systemic inflammation.
Key insight: By competitively blocking the nuclear import of the p65 subunit of NF-κB, KPV halts the expression of pro-inflammatory genes at the source. In research models, this results in a dramatic down-regulation of aggressive inflammatory cytokines like TNF-$\alpha$, IL-6, and IL-1$\beta$ without broadly turning off the host’s primary immune defenses.

PepT1-Mediated Gut Targeting

Unlike larger peptides that require complex receptor endocytosis, KPV is uniquely absorbed via PepT1 (Peptide Transporter 1), a transporter heavily expressed in the intestinal lining.

Key insight: Landmark gastrointestinal studies show that PepT1 expression naturally spikes during active intestinal inflammation. This means KPV preferentially accumulates right where tissue damage is occurring. Once inside, it actively restores tight junction integrity (claudin/occludin proteins), reducing mucosal permeability—making it an elite subject for “leaky gut,” Crohn’s, and Ulcerative Colitis research.

Melanocortin Receptor-Independent Safety

Full-length $\alpha$-MSH activates various melanocortin receptors (like MC1R), which alter skin pigmentation or hair color.

Key insight: Because KPV is stripped down to just three amino acids (Lysine-Proline-Valine), it retains 100% of the anti-inflammatory power of $\alpha$-MSH but lacks the pigment-inducing activity. Researchers can study its systemic anti-inflammatory properties without inducing melanocortin-receptor pigmentation activity or structural hormonal fluctuations.

Research Handling Notes

What preclinical and cell studies report

As an ultra-short fragment of a naturally occurring human hormone, KPV has demonstrated excellent structural safety in laboratory settings.

🧿 Reagent Handling Guidance

5%

Store Lyophilized at -20°C

lab use

3%

Reconstitute for Lab Use

lab use

0%

Protect From Light

lab use

Safety Advantage

Non-Steroidal Path

  • No Tissue Thinning: Unlike corticosteroids, KPV calms overactive immune responses without suppressing native repair signaling, thinning mucosal linings, or disrupting the adrenal axis.
  • No NSAID Complications: It bypasses the COX-1/COX-2 pathway entirely, meaning it does not carry the risks of stomach ulcers, gut bleeding, or renal strain associated with typical over-the-counter anti-inflammatories.
  • Antimicrobial Synergy: In vitro trials against pathogens like Staphylococcus aureus and Candida albicans showed KPV significantly reduced pathogen viability while dampening the inflammatory response, proving ideal for co-existing infection/inflammation models.

Compound Information

Technical specifications for this anti-inflammatory tripeptide

🔬 Molecular Profile

What Is KPV?

Type

Synthetic tripeptide

Sequence

Lys-Pro-Val (KPV)

Amino acids

3

Molecular formula

C₁₆H₃₀N₄O₄

Molecular weight

342.43 g/mol

CAS Number

67727-97-3

Origin

α-MSH residues 11-13

PubChem Database

🧊 Storage Requirements

Stability Information

Lyophilized (powder

-20°C long-term

Reconstituted

2-8°C

use within 7 days

Light protection

Store away from light

📊 Physical Properties

Research Status

Classification

Melanocortin-Derived Tripeptide Fragment

Key Discovery Phase

Preclinical Cell & Rodent Models

Primary Applications

IBD, Dermatological Research, Autoimmune Signaling

US Regulatory Status

Investigational Research Compound

Br J Pharmacol Review

Frequently Asked Questions

Common questions about KPV

No. Prednisone suppresses your body's entire immune defense, making subjects highly vulnerable to infections. KPV works selectively by modulating the intracellular NF-κB pathway. It acts as an organic brake on excessive, runaway inflammation while leaving the core immune response intact.
No. Although it is derived from $\alpha$-MSH, KPV lacks the structural profile required to bind the MC1R pigmentation receptor. In research models it acts on anti-inflammatory pathways independently of pigmentation signaling.
The gut lining contains a specific transporter called PepT1. Because KPV is an ultra-small tripeptide, it gets pulled directly through PepT1 like a key into a lock. Because PepT1 increases when the gut is inflamed, KPV naturally travels straight to the most damaged areas of the colon.
In research models, KPV is frequently studied alongside BPC-157 in tissue-repair investigations. BPC-157 focuses primarily on blood flow and cellular growth signaling, while KPV works to actively shut down the destructive inflammatory cascade.
No. KPV is an investigational research compound. While it has shown incredible promise across dozens of peer-reviewed animal and cell line studies, it has not completed formal human safety trials and is not approved for human consumption.

Sources & References

Peer-reviewed research

Gastroenterology

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

2008

Dalmasso G, Charrier-Hisamuddin L,

View Source

British Journal of Pharmacology

α-MSH Related Peptides: A New Class of Anti-Inflammatory and Immunomodulating Drugs

2000

Luger TA, Brzoska T, Scholzen TE, et al.

View Source

Molecular Pharmaceutics

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles

2017

Xiao B, Xu Z, Viennois E, et al.

View Source

Annals of the New York Academy of Sciences

Melanocortin-Derived Tripeptide KPV Has Anti-Inflammatory Potential in Murine Models of Inflammatory

2008

Kannengiesser K, Maaser C,

View Source

Journal of Investigative Dermatology

Alpha-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and

1999

Brzoska T, Luger TA, Maaser C, et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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