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DSIP

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Delta-Sleep PeptideEmideltide

A 9-amino acid peptide studied for its interaction with delta-wave sleep patterns and circadian rhythm signaling, investigated for its role in sleep onset mechanisms in research models. Premium Research Peptide.

All products currently listed on this site are for research purposes only.

Original price was: $59.99.Current price is: $53.99.

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How DSIP Works

The Science, Simplified

Delta-Wave Sleep Signaling

DSIP is a 9-amino acid nonapeptide synthesized in the hypothalamus. Unlike traditional sedatives that “force” unconsciousness, DSIP modulates circadian rhythms and delta-wave sleep architecture, promoting a natural sleep onset mechanism.
Key insight: In research models, DSIP has been studied for its association with delta-wave sleep patterns and total sleep-time measurements. Studies describe its interaction with sleep-regulatory signaling under controlled conditions.

HPA Axis & Stress Response

DSIP targets the Hypothalamic-Pituitary-Adrenal (HPA) axis, which is the body's central stress response system. It acts to attenuate the physiological and emotional responses to chronic stress.

Key insight: In research models, DSIP has been studied for its interaction with cortisol secretion and the HPA axis. This makes it a subject for studies involving stress-response signaling.

Pain Modulation & Opioid Interaction

DSIP interacts with the endogenous opioid system, influencing pain perception and antinociceptive thresholds.

Key insight: In research, DSIP has been studied for its interaction with opioid receptors; observed effects can be blocked by naloxone, indicating direct opioid-receptor involvement. This has led to research into its role in opioid-signaling models.

Research Handling Notes

What research literature describes

DSIP is characterized as a stable endogenous peptide that is naturally present in mammalian tissues.

🧿 Laboratory Handling Notes

15%

Store lyophilized at -20°C

mild

10%

Reconstitute with bacteriostatic water

mild

8%

Protect from light

mild

Safety Advantage

No Determined LD50

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is DSIP?

Type

Synthetic nonapeptide

CAS Number

62568-57-4

Molecular Formula

C35H48N10O15

Molecular Weight

848.8 g/mol

Amino Acids

9 residues

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

🧊 Storage Requirements

Stability Information

First isolated from rabbit brain in 1977 by Schoenenberger & Monnier

Lyophilized (powder)

-20°C

protect from light

Reconstituted

2-8°C

use within 24 hours

Stability

15 minutes (plasma half-life)

if kept frozen and sealed.

📊 Physical Properties

Development History

First isolated from rabbit brain in 1977 by Schoenenberger & Monnier

Discovery

1977, Switzerland

Discoverers

Schoenenberger & Monnier

Origin

Rabbit mesodiencephalic ventricle

INN Name

Emideltide

Human Studies

1980s-present

Regulatory Status

Research compound

Frequently Asked Questions

Common questions about DSIP

Technically, no. Sedatives force the brain into a state of unconsciousness, often skipping critical sleep stages like REM or Deep (Delta) sleep. DSIP acts more like a "sleep programmer," encouraging the brain to enter natural, restorative delta-wave sleep on its own
Because DSIP interacts with opioid receptors and the HPA axis, it is studied in models involving disrupted signaling from chronic substance exposure. Research describes measurable changes in these opioid-signaling models.
In research, one of the most interesting properties of DSIP is its "long-tail" effect. A single exposure in research models can be associated with normalized sleep patterns over several observation periods, suggesting an interaction with circadian signaling rather than a one-time effect.
While it is primarily associated with sleep, DSIP’s interaction with cortisol and the stress-response pathway makes it a subject for studies of daytime stress-response signaling in research models.
No. It has been extensively studied in humans since the late 1970s, but it remains an investigational research compound. It is sold strictly for laboratory use and is not intended for human consumption or medical treatment.

Sources & References

Peer-reviewed research

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.