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CJC 1295 NO DAC

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CJC/Ipa BlendPeptide Blend

A short-acting synthetic growth hormone–releasing hormone (GHRH) analog studied for its ability to stimulate pulsatile growth hormone secretion and support GH–IGF-1 axis signaling in research models. Premium Research Peptide.

All products currently listed on this site are for research purposes only.

Original price was: $64.99.Current price is: $58.49.

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How CJC 1295 NO DAC Works

The Science, Simplified

Pulsatile GHRH Receptor Activation

CJC-1295 NO DAC (commonly referred to as Mod GRF 1-29) is a synthetic analog of Growth Hormone-Releasing Hormone designed to stimulate the body’s natural growth hormone secretion patterns.
Key insight: It binds to GHRH receptors in the pituitary gland, promoting endogenous growth hormone release and downstream IGF-1 signaling without directly replacing natural GH production.

Short-Acting Pharmacokinetics

Unlike DAC-modified variants, CJC-1295 NO DAC is rapidly cleared from circulation and is studied for producing shorter, physiologic GH pulses.

Key insight: Its short half-life allows transient stimulation of growth hormone release patterns that more closely resemble natural physiologic secretion rhythms observed in normal endocrine function.

GH–IGF-1 Axis Modulation

CJC-1295 NO DAC is primarily researched for its effects on growth hormone signaling and downstream IGF-1 modulation.

Key insight: Research models have demonstrated transient elevations in GH secretion and associated anabolic and metabolic signaling pathways following exposure in research models.

Research Handling Notes

What research literature describes

CJC-1295 NO DAC has been investigated in preclinical and exploratory research settings evaluating hormone signaling and GH secretagogue activity. Research observations suggest generally stable handling characteristics under controlled study conditions.

🧿 Laboratory Handling Notes

Store lyophilized at -20°C

mild

Reconstitute with bacteriostatic water

mild

Protect from light

mild

Safety Advantage

High Selectivity

  • Studied for selective interaction with GHRH receptors
  • Short-acting profile may reduce prolonged GH exposure
  • Hormonal response varies depending on research conditions
  • Elevated IGF-1 levels may occur during extended research use
  • Long-term large-scale safety data remains limited

Compound Information

Technical specifications for this long-acting GHRH analog

🔬 Molecular Profile

What Is CJC?

Type

Short-acting GHRH analog

Alternate Name

Mod GRF 1-29

Half-life

~30 minutes

Molecular Weight

~3350–3360 Da

Sequence

Modified GRF (1-29) peptide analog

Purity

≥99%

🧊 Storage Requirements

Stability Information

Lyophilized (powder)

Store at -20°C

(Stable for up to 24 months)

Reconstituted

Store at 2–8°C

Use within 14–21 days

Light Sensitive

Store protected from direct light

to minimize peptide degradation

📋 Blend Information

Development History

Classification

GHRH analog / growth hormone secretagogue

Primary focus

Pulsatile GH release and IGF-1 signaling research

Evidence base

Preclinical studies and mechanistic endocrine research

Research interest

GH axis modulation and physiologic secretion patterns

Clinical limitation

Limited large-scale randomized human studies

Regulatory status

Investigational research compound (not FDA-approved)

Frequently Asked Questions

Common questions about CJC 1295 NO DAC

The main difference is the frequency of administration. CJC-1295 No DAC (also known as Mod GRF 1-29) has a half-life of about 30 minutes and requires multiple daily doses. CJC-1295 with DAC has a half-life of 8 days, meaning it only needs to be administered once or twice a week in a research setting to maintain high GH levels.
While it can be studied alone, many researchers pair it with a GHRP like Ipamorelin. CJC-1295 acts as the "gas pedal" for GH production, while Ipamorelin acts as the "trigger" for the release. Together, they create a synergistic effect that significantly amplifies GH output.
DAC stands for Drug Affinity Complex. It is a chemical tail (Nɛ-maleimidopropionyl-Lysine) that allows the peptide to hitch a ride on albumin, a common protein in your blood. This prevents the kidneys from filtering it out quickly, which is why it stays active for so long.
Yes, this is a term used in research to describe the constant, elevated background level of Growth Hormone. While this constant elevation is studied in some research contexts, some researchers prefer the "No DAC" version because it more closely mimics the natural "up and down" pulsatile spikes observed in physiology.
No. It reached Phase II clinical trials for growth hormone deficiency but is currently classified as an investigational research compound. It is not approved for human use or as a medical treatment.

Sources & References

Peer-reviewed research

Journal of Clinical Endocrinology & Metabolism

Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults

2006

Teichman SL, Neale A, Lawrence B et al.

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European Journal of Endocrinology

Ipamorelin, the first selective growth hormone secretagogue

1998

Raun K, Hansen BS, Johansen NL et al.

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Journal of Clinical Endocrinology & Metabolism

On the actions of the growth hormone-releasing hexapeptide, GHRP

1991

Bowers CY, Reynolds GA, Durham D et al.

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Translational Andrology and Urology

A Review of Growth Hormone Secretagogues

2018

Sigalos JT, Pastuszak AW

View Source

Translational Andrology and Urology

A Review of Growth Hormone Secretagogues

2018

Sigalos JT, Pastuszak AW

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All research data and findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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